Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. In this study we investigated the impact of aging and infection on transcription of brain NIH-PA Author Manuscript derived neurotrophic factor (BDNF), a molecule that has been shown to be important for consolidation of hippocampus-dependent memory, and for theta burst evoked L-LTP (Tyler et al., 2002; Bramham and Messaoudi, 2005; Lu et al., 2005). Hippocampus | Citations: 8,156 | Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of … Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are critical regulators of neurons and they play vital roles in neurogenesis, synapse formation, and learning and memory [13,14]. Therefore, we investigated the role of exercise and thiamine supplementation on spatial memory and on brain-derived neurotrophic factor (BDNF) and acetylcholine (Ach) content in the hippocampus of the stressed animals. J, Bergdahl. Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats ... On the other hand, stress affected hippocampal brain-derived neurotrophic factor (BDNF) signaling pathways, and increased expression of subunit of the NMDA receptor (NR2A). Posted Nov 25, 2018 Biol Psychiatry. Damage to the hippocampus can occur through prolonged exposure to stress hormones such as glucocorticoids (to which the hippocampus is particularly sensitive), highlighting the seriousness of chronic stress and its physiological impact. But not all memories are helpful. In addition, we … It is published by John Wiley & Sons and covers the neurobiology of the hippocampal formation and related structures. Walhovd, Wang, and colleagues sought to track the impact of polygenic risk across the lifespan. Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals. The hippocampus is a part of the brain that plays a key role in memory and how knowledge is obtained. Basic feedback mechanisms in the hippocampus that help modulate the release of glucocorticoids during stress may be compromised, compounding the effects … Impact of FGFR inhibitor (SU5402) on the microglia activation in hippocampus. Perceived stress in adults: prevalence and association of depression, anxiety and medication in a Swedish population. ISSN: 0953-816X. The cover image aims to represent clear, concise and artistic data visualization for the hippocampus radiomic biomarkers for AD. Self-Esteem The Hippocampus, Self-Esteem, and Physical Health New brain research on how self-esteem improves well-being. Research over the last 5 years has firmly established that learning and memory abilities, as well as mood, can be influenced by diet, although the mechanisms by which diet modulates mental health are not well understood. The founding editors-in-chief were David Amaral and Menno Witter, who were succeeded in 1998 by Howard Eichenbaum (Boston University), who remained in this position until he died in 2017. The proliferation of … Here, we show that loss of IR/IGF1R in the hippocampus and central amygdala of adult mice results in decrease in glutamate receptors, accompanied by glucose intolerance, anxiety-like behavior, and impaired cognition. PubMed Bergdahl. The hippocampus (via Latin from ... have a severe impact on many types of cognition including memory. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 2.279 ℹ Five-Year Impact Factor: 2019: 2.279 The hippocampus is subdivided into several distinct zones: the dentate gyrus (DG), CA3, ... at least in part, by increasing the expression of brain-derived neurotrophic factor (BDNF) and neurogenesis in the hippocampal and cortical circuits. Neurons and Cognition [q-bio.NC]. Neuropharmacology, Vol. The hippocampus is a vulnerable and yet resilient brain region, and excitatory amino acids play an important role in normal plasticity as well as in damage produced by ischemia, seizures and head trauma. The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. An important corticosteroid regulatory mechanism mediated via brain-derived neurotrophic factor (BDNF) in neuronal death was described in the embryonic hippocampus. 97, Issue. The noise pollution accompanying industrialization is a risk factor to human health. The journal is abstracted and indexed by: 6.3. M. 2002. ï¿¿NNT: 2013STRAJ127ï¿¿. BDNF is largely produced by astrocytes and is important in synaptic plasticity (and also neurogenesis; see section Age-related neuroinflammation and impact on hippocampal neurogenesis). About 1 in 3 people who experience severe trauma go on to develop post-traumatic stress disorder (PTSD), in which they re-live the traumatic event in the form of flashbacks and nightmares. Basic feedback mechanisms in the hippocampus that help modulate the release of glucocorticoids during stress may be compromised, compounding the effects of chronic stress by leading to chronically elevated cortisol levels. Impact Factor: 2.274 ℹ Impact Factor: 2019: 2.274 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. It has been shown in neurons from E18 rat hippocampus cultured for 1 day that corticosterone induces neuronal death. The majority were followed for an average of 11 years, with an average of nearly three years between scans. Acute influenza infection has been reported to be associated with neurological symptoms. It is published by John Wiley & Sons, and according to its Statement of Aims, "provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures".. Abstracting and indexing. Post-operative dysregulation of Brain-Derived Neurotrophic Factor (BDNF) in cortex and hippocampus of rats.