Avoid exposing the skin to sunlight after topical applications. Apart from modulating mood, serotonin plays an essential role in pain transmission and sensation. Since the herb has a high potential for drug interaction and side effects, it is advisable to take standardized extracts (such as those that have been mentioned above) and avoid taking them in combination with any other herb or medication. John's Wort (SJW) is a medicinal plant, mainly used as antidepressant, with a favourable side-effect profile. It has far less side effects than the standard antidepressants (SSRIs or tricyclics), sleeping pills and tranquilizers and pain killers. Both oral administration and topical application of St. John’s wort is proven to relieve diabetic neuropathic pain and support wound healing in diabetes. Many people use St. John's wort to help treat depression, anxiety, and ADHD. St. John's Wort For Nerve Pain. Topical St. John's wort preparations such as oils or tinctures are used for the treatment of minor wounds and burns, sunburns, abrasions, bruises, contusions, ulcers, myalgia, and many others. Iabichella ML. Any time there is sudden pain, shooting pain, or stabbing pain that indicates that nerves are involved is a good time to reach for St. Johns wort oil. St. John's wort has also been used to treat attention deficit hyperactivity disorder (ADHD), social anxiety, hepatitis C, irritable bowel syndrome, diabetic nerve pain, or burning mouth syndrome. 2014;263:27-35. Quick Gist: St. John’s wort extract contain neuroprotective agents that protect the brain and nervous system health. As a precaution, individuals should stick to normal doses since they have not been reported to cause phototoxicity under normal settings. Herbalist Marina Kesso from Iona Herbal harvesting St. John's Wort (Hypericum perforatum) flowers from the herb garden for making an oil for sciatica. Doses higher than 900 mg may increase susceptibility to photodermatitis. Your email address will not be published. I was amazed. It's just a wonderful plant, with many uses. Praxis (Bern 1994). Product description Our oils are for topical use only. Arsić I, Zugić A, Tadić V, et al. The antidepressant profile of Hypericum perforatum is comparable to that standard antidepressants. Effects of Hypericum perforatum on an Experimentally Induced Diabetic Wound in a Rat Model. In Switzerland, where St. John's Wort grows quite profusely, it is a common household remedy, and you will find beautiful red oils infusing in the windowsills in almost every home. St. John’s wort has no effect on pain in polyneuropathy. Hypericin and pseudohypericin are not extracted in the oil. It reduces oxidative stress, activates pain-relief pathways and initiates nerve repair. The pain-relieving action was pronounced and lasted for a longer duration. St. John’s Wort: A Background Scientifically known as Hypericumperforatum, St. John’s wort is a perennial shrub-like plant that bears yellow flowers and is best known for its anti-depressant properties. Topical application of the herb extract has anti-inflammatory activity comparable or even more potent than that of indomethacin, a conventional anti-inflammatory drug. Herbal poultices can also be applied directly to sore and painful joints and muscles. BMJ Case Rep. 2014;2014. Combinations like these can be used in smaller doses to relieve stress. HHS This site uses Akismet to reduce spam. St. John’s wort is one of the herbs that could benefit in nerve pain and neuropathy. St. John's Wort (SJW) is a medicinal plant, mainly used as antidepressant, with a favourable side-effect profile. I am talking about using St. John’s wort (H ypericum perforatum) infused oil that you can make in your own kitchen. 2nd edition. Topical forms of St. John's wort have been possibly effective in healing skin wounds, or treating skin irritation caused by psoriasis. Conduct a patch test prior. Considering conventional antidepressants are prescribed for pain relief in some cases, this herb seems to be a possible therapeutic agent for nerve pain. Saint John’s wort is a common ingredient in blends for depression or pain. The final product is a red colour oil which was traditionally used in Europe for treating burns and ulcers. St. John’s Wort Oil; Related Posts. Extracts of Indian Hypericum perforatum is proven to increase the anti-inflammatory and analgesic activity of conventional medicines. For menopausal symptoms, 300 milligrams St. John’s wort (Kira®) has been taken by mouth three times daily for 12 weeks and 0.4mg hypericin drops (Hyperforat®) has been taken by mouth daily for 12 weeks. Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction. For External Use Only. In the study, homoeopathic treatment with Hypericum perforatum improved myelination and regeneration of nerve fibres and assisted in faster and better recovery of peripheral nerves. Pain. Effects of treatment with St. John’s Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats. Galeotti N, Maidecchi A, Mattoli L, Burico M, Ghelardini C. St. John’s Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes. St. John’s wort (Hypericum perforatum) is a plant with yellow flowers that grows in the wild, whose medicinal uses were first recorded in ancient Greece 2). (Archives of Toxicology, 2016). Two case reports have demonstrated the therapeutic potential of St. John’s wort oil in diabetic foot ulcer. Learn more about its uses in this video featuring from Dr. JD Dudum, DC. Can ÖD, Öztürk Y, Öztürk N, et al.  |  The effects of St. John’s Wort on the nervous system permeate throughout its influence upon many other organ systems of the body, including the digestive system, urinary bladder, and musculoskeletal system. This site needs JavaScript to work properly. BMJ Case Rep. 2013;2013, Iabichella ML, Caruso C, Lugli M. The use of an extract of Hypericum perforatum and Azadirachta indica in a neuropathic patient with advanced diabetic foot. Hypericin and hyperforin have an anti-cancer property which they mediate by activating apoptotic pathways, serving as a photosensitizer and supporting the production of free radical species in cancer cells. 2013;227(1):149-63. Phytomedicines in the Treatment of Migraine. St. John’s wort oil or oil-based lotions are available. St. John’s wort or Hypericum perforatum is a flowering herb that is native to Europe but also found in temperate locations of Asia, Africa, North and South America. This activates pain signalling pathways and contributes to neuropathic pain. The herb is extracted into cold-pressed, Organic Olive oil. Also, their possible synergism or interaction with conventional neuropathy medications or potential dietary supplements must be studied. Hi. Wounds. Diabetic foot syndrome is a major complication of diabetes. Animal studies show that the herb prevents cell death and ameliorates nerve pain in peripheral neuropathy by elevating antioxidant defences. Tilgner states that St. John's wort is an anti-inflammatory, sedative and nervine, or a substance that calms your nerves. 2014;92:23-33. For pain due to burning mouth syndrome, 300 milligram capsules of St. John’s wort (containing hypericin 0.31% and hyperforin 3.0%) have been taken by mouth three times daily for 12 weeks. ), reversed mechanical hyperalgesia with a prolonged effect, being effective up to 180 min after injection. Also you can click on the blue links in the article, they will direct you to the studies. As a topical remedy in limited use, the product doesn’t present harmful side effects. Made with Aloha, in Hawaii Available in 3 sizes! You can apply the infused oil (in case of essential oil, please dilute before use) directly to the affected area (such as lower extremities) 2-3 times a day. St. John’s wort may cause increased sensitivity to sunlight, especially when taken in large doses. Tricyclic antidepressants are prescribed for neuropathic pain. As a standalone supplement, St. John’s wort is safe, but when taking other medications, there is a risk for potential drug interactions. Furthermore, SJW showed a dual mechanism of action since hyperforin antinociception involves an opioid-dependent pathway. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Topical St. John's wort preparations such as oils or tinctures are used for the treatment of minor wounds and burns, sunburns, abrasions, bruises, contusions, ulcers, myalgia, and many others. St John’s wort is traditionally used for conditions that affect the nervous system including depression, anxiety and neuralgia. This is an essential herb-infused oil in my DIY pantry. J Ethnopharmacol. St. John's Wort is a homeopathic medicine used to treat acute and rapid nerve pain. Ion channels are gateways that restrict entry of compounds in the cells. St. John’s wort has a strong reputation as a natural antidepressant. St. John's wort is a herb containing hypericin, which seems to give it antibacterial and antiviral properties. Volmer-Thole M, Lobmann R. Neuropathy and Diabetic Foot Syndrome. Topical forms of St. John's wort have been possibly effective in healing skin wounds, or treating skin irritation caused by psoriasis. Galeotti N, Ghelardini C. Reversal of NO-induced nociceptive hypersensitivity by St. John’s wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. It is 100% natural, derived from plants, and does offer “therapeutic relief,” especially from St. John’s Wort. Quick Gist: Findings of a pre-clinical study suggest that St. John’s wort extract may help in counteracting oxaliplatin-induced neurotoxicity and prevent chemotherapy-induced peripheral neuropathy. 2019 Jul 3;12:2039-2052. doi: 10.2147/JPR.S213912. St. John’s wort oil is an amazing home remedy for minor burns. Neuropathic pain is a common side of oxaliplatin-based chemotherapy. He had pain and almost no functional use. They benefit in Alzheimer’s, Parkinson’s, alcohol addiction, memory impairment and brain injury. Topical forms of St. John's wort have been possibly effective in healing skin wounds, or treating skin irritation caused by psoriasis. The burn was gone within hours, and the pain almost immediately. 2013;17(8):1082-9. How to make Saint John's wort oil yourself (according to Maria Treben) J Ethnopharmacol. Protein kinase C is a group of enzymes that have multiple functions including that of pain processing. These are standardised to contain 0.3% hypericin. COVID-19 is an emerging, rapidly evolving situation. Clipboard, Search History, and several other advanced features are temporarily unavailable. However, its astringent and anti-inflammatory properties can be useful in treating sciatica as well. Inhibitory effect of St. John׳s Wort oil macerates on TNFα-induced NF-κB activation and their fatty acid composition. Sosa S, Pace R, Bornancin A, et al. Read honest and unbiased product reviews from our users. Read more. Topical application of St. John’s wort oil is traditionally used to relieve nerve pain. Further, Galeotti and Ghelardini have proven that St. John’s wort extracts act on the pain signalling pathways in the spine to reverse nerve pain and allodynia (pain in response to a stimulus that usually does not cause pain). You can apply the infused oil (in case of essential oil, please dilute before use) directly to the affected area (such as lower extremities) 2-3 times a day. Many people use St. John's wort to help treat depression, anxiety, and ADHD. Two patients with diabetic neuropathy and severe diabetic foot ulcers were treated with a topical application of St. John’s wort and neem (Azadirachta indica) oil. Some of the best topical pain relievers are: 2014;155(2):1086-92. Salubrainous aims to provide well researched data for brain and nervous system care. Applying SJW oil directly to the rash can help to reduce the pain. Patrick J. Mansky, Stephen E. Straus; St. John’s Wort: More Implications for Cancer Patients. There is no specific dosage of St. John’s wort prescribed for peripheral neuropathy; human studies are awaited. St. John’s wort has a reputation of natural and powerful antidepressant. In Switzerland, where St. John's Wort grows quite profusely, it is a common household remedy, and you will find beautiful red oils infusing in the windowsills in almost every home. Note: The severity and symptoms of peripheral neuropathy differs with every individual. 1 fl oz metal tin with labeled ingredients and directions for use. The authors commented that further research must be conducted before using H. perforatum as a treatment option for trigeminal neuralgia. 2010;5(9):1493-506. Epub 2012 Dec 20.  |  Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification. Major molecular components of the herb benefit brain and nervous system health either by their neuroprotective action or indirectly by antioxidant activity. It acts as an antioxidant, preventing damage to the nerves, reduces inflammation and provides pain relief. J Pharm Pharmacol. Clean Liquid extracts and topical preparations are also used. Galeotti N, Vivoli E, Bilia AR, Vincieri FF, Ghelardini C. St. John’s Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. 2013 Mar;17(3):369-81. doi: 10.1002/j.1532-2149.2012.00196.x. Used topically, it has anti-inflammatory properties that make it useful in cases of nerve inflammation such as sciatica and neuralgia and for recovery from wounds/injuries where there has been nerve tissue damage. Few drugs that Hypericum perforatum may interact with are fexofenadine, digoxin, anti-cancer drugs, warfarin, immunosuppressive agents, ivabradine, oral contraceptives, anti-HIV drugs, anti-fungal agents, antidepressants and other drugs for psychiatric conditions, benzodiazepines etc. Home » Neurological Diseases » Neuropathy » St. John's wort for Neuropathy, What is St. John’s wort | How it works | Research | Dosage and Uses | Side Effects & Precautions | Suggested Products | Conclusion. This may influence the use/ effectiveness of dietary supplements, herbs and alternative treatments for the disorder. Galeotti N, Maidecchi A, Mattoli L, Burico M, Ghelardini C. Fitoterapia. The primary active compound extracted in the oil is hyperforin and adhyperforin. Other constituents include monoterpenes, sesquiterpenes and hydrocarbons. We assure herb identity via macroscopic and organoleptic analysis, then confirm it through methods such as HPTLC fingerprinting specific to each herb. The researchers concluded that Hypericum perforatum could be a ‘novel strategy ‘ for treating chemotherapy-induced peripheral neuropathy. You can also put 2-3 drops of the infused oil on a gauze and cover the affected region. A study published in The Journal of Ethnopharmacology, 2017 highlights the role of St. John’s wort in pain management. Quick Gist: Oral consumption of St. John’s wort extract benefits in diabetic neuropathy by relieving nerve pain, supporting wound healing and lowering blood sugar levels. Because St. John's wort can interfere with certain medications, it is always best to consult with a doctor before usage. Velázquez KT, Mohammad H, Sweitzer SM. Eur J Pain. The mechanism of action of Hypericum perforatum comprehends a neurotransmitter inhibitory profile, and potential anti-inflammatory and anti-oxidant effects suggesting a role for pain management. It is 100% natural, derived from plants, and does offer “therapeutic relief,” especially from St. John’s Wort. According to the University of Rochester Medical Center, St. John’s wort may be used to ease pain associated with sciatica and rheumatoid arthritis. 2017;200:136-146. St. John’s wort supplements contain extracts from flower, leaf and stem. Home › Forums › General Forum (now closed, but readable and searchable) › St. John's Wort For Nerve Pain. The antihyperalgesic profile and mechanism of action of SJW and its main components were studied in two rat models of neuropathic pain: the chronic constriction injury and the repeated administration of oxaliplatin. Please consult a suitable healthcare provider for the dosage. 2007;59(5):703-9. Farsak M, Özdağli G, Özmüş D, et al. Everything You Should Know About Dental Implants . Z Naturforsch, C, J Biosci. Hello, which supplements are available for taking internally with.st John’s sort, are there capsules or pills or the oil to take, I mean internally beside the.homeopathic remedy which is available. specific mild nervine sedative, trophorestorative, and anodyne for nerve pain. However, this multipurpose herb is so much more than a simple blues fighter. It helps to stop the pain and heal the burn. Dec 21, 2020. Chemotherapy-induced neurotoxicity contributes to peripheral neuropathy and limits treatment adherence in cancer patients. Prized for its various health benefits, St. John’s Wort is famous for its depression-reducing qualities. Please consult a health practitioner before taking St. John’s Wort supplements. (Read 4 Evidence Based Benefits Of St. John’s wort For Peripheral Neuropathy) Olerum Hyperici is the oil extract of St. John’s wort flowers. Galeotti N. Hypericum perforatum (St John’s wort) beyond depression: A therapeutic perspective for pain conditions. The pain-relieving activity of the herbs is comparable to that of conventional medicines carbamazepine, lamotrigine, l-acetyl-levocarnitine. St John’s Wort . Biomol Ther (Seoul). Herbal and homeopathic forms of St. John's Wort have different indications and different guidelines for their usage. Nat Prod Commun. Various case studies and user reports have mentioned that topical application of St. John’s wort oil relieves nerve pain. Peripheral neuropathy leads to pain, loss of sensation and impaired wound healing in diabetic foot ulcer. Psychopharmacology (Berl). (Mabey,Richard ,41) Sore muscle pain Therapeutic massage with herbal oils, liniments, and essential oils can be used with great results. Herb Pharm St. John's Wort Topical Oil Description: Our oils are for topical use only. Find helpful customer reviews and review ratings for Herb Pharm St. John's Wort Topical Oil - 1 Ounce at Amazon.com. 2017;72(5-6):219-226. Further examinations of the SJW main components revealed that hyperforin and hypericin were responsible for the antihyperalgesic properties whereas flavonoids were ineffective. Nine patients in the herb group and two in the placebo group experienced complete or moderate pain relief. 1998;352(9134):1121-2. For any questions relating to medical matters and health conditions, please seek advice from your doctor or other healthcare professionals. Hypericum perforatum (St. John’s Wort) is an alternative remedy used primarily for depression but also is used for rheumatism, gastroenteritis, headache and neuralgias. Multiple mechanisms in the body act together to transmit pain. A comparison with standard antidepressants in animal models of depression. This herb, notes Tilgner, helps relieve pain associated with nerve pain, along with numbness, tingling and burning -- symptoms commonly associated with sciatica. Dec 23, 2020. In an animal model of nerve injury, St. John’s wort supplementation is proven to reduce inflammation and improve antioxidant defences to support the recovery of damaged nerves. Fitoterapia. Klemow KM, Bartlow A, Crawford J, et al. Galeotti N, Vivoli E, Bilia AR, Bergonzi MC, Bartolini A, Ghelardini C. A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John’s Wort in mice. Cinci L, Di cesare mannelli L, Maidecchi A, Mattoli L, Ghelardini C. Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations. Bove GM. The most common side effects of St. John’s wort are gastrointestinal symptoms, mouth dryness, confusion, lethargy, restlessness, dizziness and allergic reactions. 2019 May;33(5):399-415. doi: 10.1007/s40263-018-0597-2. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.  |  2000 Dec 14;89(50):2111-21. It regulates neurotransmitter levels and activates pain relief pathways to reduce neuropathic pain. Hypericum perforatum contains different classes of active ingredients and essential oils; two major constituents are hypericin and hyperforin. Orhan et al. Despite its potential use in cancer therapy, St. John’s wort is not actively recommended as a natural anti-cancer agent due to the high risk of possible drug interactions. 2010;11(2):149-59. J Ethnopharmacol. Neuroscience. (NB: This oil is for topical use only and shouldn’t be consumed internally). Quick Gist: St. John’s wort helps in pain management by regulating the endogenous opioid system and inhibiting other proteins involved in nerve pain. St. John’s wort oil or oil-based lotions are available. Transient Receptor Potential cation channel and Voltage-Gated Calcium Channel are two of the important ion channels that are activated in neuropathic pain. ♥ Application and More Info ♥ Generally salves should be applied twice daily. The combination of St. John’s wort seed extract and Feverfew flower extracts is found to reverse chronic diabetic neuropathic pain for a prolonged duration. For any possible queries, please get in touch with us via Contact Us. The effect of SJW on the PKC expression and activation was investigated in the periaqueductal grey (PAG) area by immunoblotting experiments. St. John's wort is a herb containing hypericin, which seems to give it antibacterial and antiviral properties. In more recent years, scientific research has supported use of Hypericum for other nervous system complaints, such as anxiety and depression. Inflammation, oxidative stress and activation of cell death pathways are few of the biochemical or pathological processes occurring in peripheral neuropathy. We assure herb identity via macroscopic and organoleptic analysis, then confirm it through methods such as HPTLC fingerprinting specific to each herb. However, its astringent and anti-inflammatory properties can be useful in treating sciatica as well. Named after St. John the Baptist, this plant goes into full bloom every 24th of June, which is also the feast of the Catholic saint. Kumar V, Singh PN, Bhattacharya SK. Copyright 2019 © Salubrainous | Shrutaavat Media. They observed that the extract demonstrated antioxidant activity and prevented activation of cell death pathways in normal cells. Our results indicate SJW as a prolonged antihyperalgesic treatment through inhibition of PKC isoforms and their phosphorylation. A type of anxiety marked by fear in some or all social settings (social anxiety disorder). 2011;82(4):576-84. Another difference is that homeopathic Hypericum comes in very diluted form and is FDA approved and regulated. The flowering tops of St. John’s wort are used to prepare teas, tablets, and capsules containing concentrated extracts. Hypericin has a phototoxic effect that may cause photodermatitis when taken at high doses. St. John's wort has also been used to treat attention deficit hyperactivity disorder (ADHD), social anxiety, hepatitis C, irritable bowel syndrome, diabetic nerve pain, or burning mouth syndrome. Molecules. As it treats the nervous system, it’s a great herb to use in conjunction with other nervines such as oats. After two years, he had regained the use of the arm enough to again play the saxophone. Pharmacological research supports the use in these fields.. St. John's Wort oil can also be used to help treat breast engorgement during the lactation period as it helps relieve the tenderness of the breast. Anand P, Elsafa E, Privitera R, Naidoo K, Yiangou Y, Donatien P, Gabra H, Wasan H, Kenny L, Rahemtulla A, Misra P. J Pain Res. It is involved in the sensation of nociceptive pain ( pain in response to exposure of extreme temperatures or pain in response to a stimulus that usually does not cause pain), and its inhibition can help relieve neuropathic pain. Hohmann N, Maus A, Carls A, Haefeli WE, Mikus G. St. John’s wort treatment in women bears risks beyond pharmacokinetic drug interactions. Current pharmacological treatments for neuropathic pain have limited efficacy and severe side-effect limitations. Rats undergoing treatment with SJW and purified components did not show any behavioural side effects or signs of altered locomotor activity. specific mild nervine sedative, trophorestorative, and anodyne for nerve pain. It works similar to conventional antidepressants. St. Johns Wort oil can be used liberally in external applications like massage oil, salve, or lotion bars. Coluzzi F, Mattia C. Mechanism-based treatment in chronic neuropathic pain: the role of antidepressants. Almost 20 years ago I published an article describing how St. John's Wort could be used for nerve regeneration. (The Journal of Pain, 2010). Curr Pharm Des. It is believed that St Johns wort works by raising levels of the chemical serotonin in the brain, thus helping to boost mood. Dec 21, 2020. St. John’s wort helps in peripheral neuropathy by relieving nerve pain and supporting nerve repair. The herb is extracted into cold-pressed, Organic Olive oil. Although it’s best known for its anti-anxiety and anti-depressant properties, St. John’s wort may also be effective at alleviating nerve pain. Pharmacological research supports the use in these fields. St. John's wort relieves pain in an animal model of migraine. Product description Our oils are for topical use only. I use it regularly along with calendula infused oil in many of my DIY Herbal salves. Due to its anti-inflammatory properties, St. John's wort may also be helpful in treating your arthritis. We here demonstrate the ability of SJW to relieve neuropathic pain in rat models. Hope. In the case of tinctures, it is best to consult a herbalist about the dosage and safety. Mohammadi R, Amini K, Charehsaz S. Homeopathic treatment for peripheral nerve regeneration: an experimental study in a rat sciatic nerve transection model. CNS Drugs. Neuroprotective Activity of Hypericum perforatum and Its Major Components. Topical forms of St. John's wort have been possibly effective in healing skin wounds, or treating skin irritation caused by psoriasis. NLM Friday, September 19 th, 2014 HYPERICUM PERFORATUM (ST. JOHNS WORT) Hypericum is an excellent homeopathic remedy for injuries to nerves or to injured parts of the body which are richly supplied with nerves (fingers, toes, the spine). 2011;17(1):275-94. Science has proven the benefits of St. John’s wort for treating depression and mood disorders, infectious conditions, cancer, wound healing etc. Protein kinase C in pain: involvement of multiple isoforms. The use of an extract of Hypericum perforatum and Azadirachta indica in advanced diabetic foot: an unexpected outcome. Please consult a herbalist or homoeopathic practitioner about the right dose. Please enable it to take advantage of the complete set of features! Eur Rev Med Pharmacol Sci. Antidepressants regulate neurotransmitter levels, interfere with the endogenous opioid system’s function, and interact with other receptors and ion channels; these activities indirectly aid in pain relief. NIH Bukhari IA, Dar A. Behavioral profile of Hypericum perforatum (St. John’s Wort) extract. Today, a significant number of in vitro, in vivo and epidemiological studies provide substantial evidence that St. John´s Wort and its active compounds are effective for treatment of mild to moderate depression. Viewing 15 posts - 1 through 15 (of 22 total) 1 2 → Author. Total pain scores were reduced in the herb group compared to placebo, but no significant changes in individual pain ratings were observed. Keep massaging the affected area (s) with Saint John's wort oil. 54 patients (out of which 18 had diabetes) were  treated with three tablets of the herb containing 900 micrograms of total hypericin or placebo for 5 weeks.Patients were asked to rate various pain-related parameters. 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I, Zugić a, Tadić V, Governa P, Biagi M st john's wort topical for nerve pain... N. BMJ Open, et al potential therapeutic agent for nerve pain Öztürk N, a. Journal of Ethnopharmacology, 2017 highlights the role of antidepressants form and is FDA and. Herb that produce analgesia side-effect profile the authors commented that further research must be conducted using. Johns wort, Beeswax, and anodyne for nerve pain in peripheral ;! Brain and nervous system, it is always best to consult with doctor!